effects of glp-1 on appetite and weight GI Adverse Glucagon-Like Peptide-1 Receptor Agonists GLP-1 Therapy Part 1: Setting

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We report here the hormonal, metabolic and gonadal responses to the glucagon-like peptide-1 (GLP1)-based multi-agonists, GLP1/Estrogen (GLP1/E), GLP1/gastric inhibitory peptide (GLP1/GIP) and GLP1/GIP/Glucagon, in two mouse PCOS models, with variable penetrance of metabolic and reproductive traits, and their comparison with metformin

In preclinical models, chronic GLP-1 administration improves depression-like behaviors even in lean animals, an effect not mediated by weight loss