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The superoxide anion radical (O 2 ) spontaneously dismutes to O 2 and hydrogen peroxide (H 2 O 2 ) quite rapidly (~10 5 M 1 s 1 at pH 7)

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to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction or non-fatal stroke) in adults with type 2 diabetes and established cardiovascular disease