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With semaglutide, the primary mechanism is appetite suppression, so ensuring adequate protein intake is critical to minimize lean mass loss during the caloric deficit

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Supplementation with vitamin B12 significantly decreased serum levels of homocysteine compared to placebo at the end of 12 weeks

Since vitamin B 12 is a determinant of homocysteine metabolism, it was suggested that the risk of osteoporotic fractures in older subjects might be enhanced by vitamin B 12 deficiency