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This caution comes mainly from cosmetic formulators rather than from dermatology trials, and the evidence is limited, so it is not something to state as a hard rule

Furthermore, direct comparisons of GLP-1RAs and exercise in diverse populations are scarce, and evidence on optimal sequencing, duration, and integration of hybrid interventions remains limited ( Beyond physiological adaptations, treatment adherence and long-term success largely depend on motivation, self-efficacy, and body-image perception, which may fluctuate during pharmacologic weight loss (65), self-regulation, and a positive relationship with the body, promoting sustained engagement even after pharmacotherapy discontinuation