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Manoj Kumar Mahapatra, Q

W.WolfR.KosankeS

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1.3 Testing strategies Currently, there are no existing test guidelines, approaches or testing strategies for metabolic disrupting chemicals, but the need for such methods has been expressed in a number of international and European reports ( For regulatory purposes, test methods need to demonstrate that they are able to address the intended chemical applicability domain and to classify chemicals correctly ( In vitro test method tools can provide mechanistic information to elucidate the modes of action leading to apical adverse outcomes, thereby contributing to the reduction of in vivo testing ( in vivo data, new approach methodologies (NAMs) can also provide concentration-response information