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It is unfeasible as a therapy for obesity or diabetes, as patients would essentially need to be tethered to a continuous intravenous infusion

References Biomedicines (2022) Stable gastric pentadecapeptide BPC 157: pleiotropic beneficial activity and neurotransmitter interactions Current Pharmaceutical Design (2018) BPC 157 and standard angiogenic growth factors: gastrointestinal tract healing and angiogenesis Annals of the New York Academy of Sciences (2007) Thymosin 4: roles in development, repair, and regeneration Expert Opinion on Biological Therapy (2018) Thymosin 4: a multi-functional regenerative peptide

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Proponents also claim that coffee enemas dilate bile ducts and enhance toxin elimination