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A case-control study involving 4,995 cancer patients and 4,972 controls from a Chinese population found that a variant in the Caspase-8 gene was associated with reduced susceptibility to several cancers, including lung, esophageal, gastric, colorectal, cervical, and breast cancers

FOXO4-DRI is a D-Retro-Inverso (DRI) isoform peptide a synthetic peptide in which the amino acid sequence of the FOXO4 p53-binding domain has been reversed and all L-amino acids substituted with their D-amino acid counterparts

These findings suggest that DSIP can cross the blood-brain barrier through a simple diffusion process, which helps explain how it can have effects on the brain