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Indeed, the history of anti-obesity medications has been marked by several failures due to serious adverse events, such as suicidality, observed only after their usage had become extensive 221,234 a well-known example being the one that led to the withdrawal of the endocannabinoid inverse agonist, rimonabant 235
PubMed Central PMCID: PMC6613229
Common side effectsnausea, vomiting, constipation, and loss of appetiteare dose-dependent and often decrease over time as your body adjusts
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