Most incretin weight-loss therapies are injected subcutaneously, but oral semaglutide is already licensed in the UK for T2DM as Rybelsus, while its manufacturer Novo Nordisk has published positive phase III results (OASIS-4, NCT05564117) for its 25mg semaglutide pill for weight loss 6
To mitigate risk: do not severely restrict fat to zero a moderate amount of fat in your diet (like the healthy fats we discussed) actually helps keep the gallbladder active and less likely to form stones
( 10.1111/jgh.13026) [DOI] [PubMed] [Google Scholar] 54.Armstrong MJ, Gaunt P, Aithal GP, Barton D, Hull D, Parker R, Hazlehurst JM, Guo K.LEAN Trial Team, Abouda Get al
Clinical evidence, encompassing trials, epidemiological investigations, and findings from animal toxicology and histological studies, has revealed potential associations between GLP-1RAs and the risk of neuroendocrine tumors and exocrine pancreatic dysplasia, with some evidence suggesting an increased risk of pancreatic cancer [6]