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A vitamin B12 deficiency in humans can also cause anemia, neurological problems, and even developmental delays in children

Mechanistically, ART suppressed nuclear localization of SREBP2 in MM cells, accompanied by downregulation of IPP and GPX4, suggesting its capacity to trigger ferroptosis through SREBP2 nuclear localization inhibition and subsequent IPP/GPX4 suppression (Liang et al., 2023)

After a single hydroxocobalamin injection, therapeutic levels can be maintained for approximately 8 to 12 weeks in most patients, which aligns with the standard maintenance schedule of injections every 2-3 months recommended in the British National Formulary (BNF)

doi: 10.1210/er.2015-1104 42 KolheJVChhipaASButaniSChavdaVPatelSS