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Strategies to reduce the issue: Take with food (for oral formulations) Follow administration with a beverage Consider alternative delivery formats (injection, topical) if taste is bothersome Time doses to minimize coincidence with meals where possible Other Safety Considerations Pregnancy and lactation

Olfaction has been recognised as having significant impact on the control of energy balance 16,34 and olfactory disorders have been shown to influence eating behaviour and whole-body metabolism 11

With proper management of reflux symptoms, many patients can safely use semaglutide over the long term

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