once-weekly semaglutide in adults with overweight or obesity once a week obesity, with or without type 2 diabetes in an east Asian population (STEP 6): a randomised, double-blind, double-dummy, placebo-controlled, phase 3a trial Effect of once-weekly semaglutide on

International Consensus for Diagnosing Lipedema: Uncontrolled localized deposition of fat in the lower extremities Symmetric increase in adipose tissue (two-body syndrome) Onset at puberty, pregnancy, and menopause Women (usually progressive with age) Easy Bruising Tired or heavy legs Mild or severe pain or pressure to touch Hands and feet are usually spared Cuffing or bulging at the joints Stemmers sign is negative Nodules of fat are palpable Limited mobility and decreased social activity* *Adapted from Sandhofer M, et al

A more comprehensive and systematic evaluation is needed to elucidate their underlying mechanisms, therapeutic potential, and challenges that must be addressed to maximize their efficacy across various pain modalities

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Klein RZ, Haddow JE, Faix JD, Brown RS, Hermos RJ, Pulkkinen A, et al