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Glutathione as a signaling molecule: another challenge to pathogens

CPS1 is a key enzyme in the urea cycle and is directly related to ammonia production.CPS1 is significantly under-expressed in hepatocellular carcinoma tissues and circulating tumor cells, and its down-regulation may be associated with hypermethylation of CpG in its promoter region, which is negatively correlated with the stage and prognosis of HCC(Chen et al

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