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This post hoc analysis used the data from the Adjunct Semaglutide Treatment in Type 1 Diabetes (ADJUST-T1D) trial, a double-blind, multicenter, randomized, placebo-controlled trial of semaglutide 1 mg/week in adults with type 1 diabetes [[T1D]and obesity), to evaluate the relationship between insulin dose reduction and weight loss

This inevitably results in low IGF-I and high GH that may stray into the acromegaly range (132, 133) and this catabolic state is comparable to prolonged fasting and malnutrition states ( Figure 1E )

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Clinical trials combining these agents reported 35-40% discontinuation rates when both were dosed together