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TSC2 forms a heterodimeric complex with TSC1 that suppresses the mTOR complex 1 (mTORC1) activity by inhibiting the small GTPase Rheb, an essential mTORC1 activator [263]

doi: 10.3389/fendo.2025.1533209 Received 23 November 2024 Accepted 16 January 2025 Published 10 February 2025 Volume 16 - 2025 Edited by Alessandro Cavarape, University of Udine, Italy Reviewed by Graziano Grugni, Italian Auxological Institute (IRCCS), Italy Svetlana Ten, Richmond University Medical Center, United States Updates Copyright 2025 Dinoi, Daniele, Michelucci, Baldinotti, Campi, Marchetti, Del Prato and Dardano