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Izabella Wentz, Pharm.D., FASCP is a passionate, innovative and solution focused clinical pharmacist and NY Times Best Selling Author

OSA may also complicate asthma owing to specific inflammatory changes of the airways with predominance of neutrophils and C-reactive protein (CRP) as well as the presence of the cytokine interleukin 8 with subsequent changes in the thickness of the basement membrane and remodeling of the airway [56]

There was a complete absence of toxic outcomes or adverse side effects in both trials

However, substantial heterogeneity among studies was observed, likely attributable to differences in dosage, baseline B12 status, and population characteristics