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PDI is S-nitrosylated in lumbar spinal cords of sporadic ALS patients (Walker et al., 2010), which abrogates PDI-mediated attenuation of neuronal cell death triggered by ER stress or misfolded proteins (Uehara et al., 2006)

As the precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), riboflavin is indispensable for redox reactions, mitochondrial respiration, and maintenance of myelin integrity (3)

45 Thus, although no specific limitations on APAP intake have been proposed based on ethnic background, further studies on this topic may yield useful clinical information about the safety profile amongst a diverse patient population

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