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Several in vivo studies utilizing animal models have shown the essential role of GSH in lowering cellular oxidative stress

In this strain, the cytosolic sensor was more oxidized compared to the wt, however not to the extent found in a glr1 strain, while the matrix sensor exhibited a steady state almost identical to the sensor expressed in the wt background

Here it will be transported through several intermediate endosomal vesicles which are maturated by their fusion and fission until reaching the lysosomes [22, 23]