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The second co-stimulatory signal arises from the engagement of B7.1 (CD80) and B7.2 (CD86) molecules on APCsincluding activated macrophages, dendritic cells, and B cellswith CD28 on T cells

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At the cellular level, BPC-157 has been linked to activation of repair-associated signaling pathways, including Egr-1 with its regulator NAB2, and FAKpaxillin signaling, which are potentially involved in cell adhesion and migration