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Pharmacokinetics, dose-response, and safety at these regimens havent been characterized in major peer-reviewed clinical trials

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10.1016/j.bbr.2010.02.032

Although many studies have failed to measure NRF2 expression after sleep deprivation, most available data from systematically reviewed animal studies suggest an increased expression of key antioxidant enzymes regulated by NRF2, such as GSH, GPx, CAT, and SOD (Villafuerte et al