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338,341 Astrocytic glutamine synthetase is reduced in post-mortem tissues from epilepsy patients
These medications have been extensively studied in large-scale clinical trials and are licensed by the MHRA for specific indications including type 2 diabetes and, in some cases, weight management, as outlined in NICE guidance (NG28)
However, these results were obtained using methods with serious limitations (e.g., based on boronate or dichloroflorescin diacetate probes) and may not be relevant in vivo , as previously reviewed elsewhere (Murphy et al., 2011