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Funding This work was supported by the National Natural Science Foundation of China (81901006, 82372905), the Young Top-notch Talent of Pearl River Talent Plan (0920220228), the Guangdong Provincial Science and Technology Project Foundation (2022A0505050038), Science and Technology Program of Guangzhou (No.2025A04J3464), and Science Research Cultivation Program of Stomatological Hospital, Southern Medical University (PY2020002, PY2022019)

Smoke is produced both when a cigarette is actively puffed (mainstream smoke) and when it smolders between puffs (sidestream smoke)

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BOLD TOBACCO ALTERNATIVE Enjoy the BOLD look, feel, and burn of a cigarette without tobacco or nicotine