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This is the SAFA trial protocol, the Endocrine Societys recommendation, and a sensible starting point it lets the body adapt to the diuretic effect (and the inevitable extra bathroom trips) before pushing the dose up

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These include: Aspirin Ibuprofen Naproxen If you take these medications regularly for headaches or joint pain, you may notice that you bruise more easily from your weekly injections

Keller et al., 1985)