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Jan 7: 2015;4:e001355

Done AJ, Traustadttir T

S-glutathionylation is supposed to occur directly by GSH, but it is also accelerated by the enzymatic action of GSTs and at the same time be reversible by glutaredoxins

Despite its potent anti-diabetes effects, the clinical application of native GLP-1 is hindered by its rapid clearance by the dipeptidyl peptidase-4 (DPP-4) enzyme in vivo, resulting in a half-life of only 2 minutes [17, 18]