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[2] For patients new to injectable semaglutide, healthcare providers typically initiate therapy at a lower dose (0.25 mg weekly for Ozempic and Wegovy) and gradually titrate upward every four weeks to minimize gastrointestinal adverse effects

the PYD domain of ASC interacts with the PYD of inflammasomes, and its caspase activation domain and CARD domain interact with the CARD of Caspase-1 to form the NLRP3 complex