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additional contraceptive methods are advised for 4 weeks after starting treatment and after each dose increase Patients with severe gastrointestinal disease (e.g., gastroparesis) should generally avoid Mounjaro If the patient is on insulin, doses should not be rapidly reduced when starting Mounjaro, as this increases the risk of diabetic ketoacidosis Patients should be counselled to report symptoms suggestive of thyroid C-cell tumours (neck mass, difficulty swallowing, persistent hoarseness) A collaborative approach involving endocrinologists, GPs, and diabetes specialists is often beneficial to ensure comprehensive care and monitoring

Additionally, your doctor might explore transitioning you to more cost-effective oral medications, such as metformin or naltrexone/bupropion, to help you maintain your progress after tapering off completely

Cardiovascular outcome trials (CVOTs) with GLP-1RAs evaluated seven agents, with liraglutide, semaglutide, and dulaglutide showing significant CV and renal benefits

The new study doesnt entirely answer the question of leptins potential, Drucker said, noting that it was a short-term study conducted over 18 days and focused on animals that dont have a lot of fat