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CagriSema is not one drug but a fixed combination of two peptides designed to hit appetite and metabolic control through two complementary hormonal pathways at the same time

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Forkhead box protein O4 (FOXO4) is an anti-apoptotic transcription factor which is upregulated in some senescent cells and prevents cell death by sequestering the nuclear protein p53 (70)

Acknowledgements We thank Alexander Jetter for the discussion on colistin pharmacokinetics, as well as Larissa Govers from Christian Grimms lab for the donation of mouse kidneys from cadavers for the isolation of mitochondria