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The findings that loss of claudin-7 expression induces sloughing of intestinal epithelial cells (claudin-7 KO mice), possibly by disrupting the complex between claudin-1, claudin-7 and 1-integrin, highlights the previously underappreciated roles of TJ proteins in cellmatrix interactions

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This reinforces the importance of looking beyond a single point-in-time measure, Poulopoulos said, noting that underwriters increasingly consider broader indicators of metabolic health and weight history rather than current BMI alone