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Norepinephrine reuptake inhibition: Increases metabolic rate (thermogenesis) Enhances fat oxidation Suppresses appetite centrally Increases energy expenditure Also increases heart rate and blood pressure (side effects) 3

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Regulatory status and legal considerations The legal landscape for these compounds is quite different, and understanding the regulatory environment matters for practical decision-making

Zepbound is approved for chronic weight management in adults with obesity or overweight with at least one weight-related comorbidity