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The observed upregulation of oxidative and lipolytic gene networks, together with metabolomic signatures indicating enhanced -oxidation, reduced accumulation of acyl-carnitines, and restoration of peroxisome activity, support the notion that Retatrutide is associated with pronounced adipose metabolic reprogramming toward a catabolic state

Similar to these studies, there are studies in which vitamin C (Reference Savran, Cicek and Doguc7) , resveratrol (Reference zgmen and Yeilot44) , quercetin (Reference Yuksel, Yuksel and Yagmurca45) , berberine (Reference Mehrzadi, Fatemi and Esmaeilizadeh48) and gallic acid (Reference Olayinka, Ore and Adeyemo43) were used to treat MTX-induced tissue damage

Include other omics techniques to discover novel biological changes and endpoints