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Post-translational modifications, especially those in the DNA binding domain of FOXO4 protein, appear to modify its functionality as a transcription factor and regulation of pathways such as apoptosis, cellular senescence, insulin signaling, and senescence

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The current MDL, established in February 2024, involves claims against Novo Nordisk alleging failure to warn patients about severe gastrointestinal complications including gastroparesis and vision loss from non-arteritic anterior ischemic optic neuropathy (NAION)