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In addition to PDHC and OGDH(L)C, this action of thiamine is mediated by two other ThDP-dependent multienzyme complexes, i.e., those of branched chain 2-oxo acid dehydrogenase (BCODH) and OADH, functioning in the pathways of degradation of branched-chain -amino acids, and lysine and tryptophan, respectively (Figure 1)

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The dura mater, a highly vascularized layer with fenestrated capillaries, harbors border-associated macrophages (BAMs), T cells, B cells, and dendritic cells that detect and respond to peripheral immune signals