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OPA1 has a role in maintaining cristae structure and DNA integrity in addition to its role in fusion, with loss of OPA1 causing mitochondrial fragmentation and autophagy of the damaged mitochondria ( 5.2 Influence of altered mitochondrial dynamics on inflammation Altered mitochondrial dynamics, which include the processes of mitochondrial fission, fusion, biogenesis, and mitophagy, play a critical role in regulating cellular homeostasis and can significantly influence inflammatory responses ( Mitophagy is the selective autophagic removal of damaged mitochondria, crucial for mitochondrial quality control

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Statistical Profile of Childrens Health in Northern Ireland