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It has not been evaluated by bodies like the United States Food and Drug Administration (FDA) or comparable international agencies, leading to a significant gap in understanding its safety for human use

Hanno et al., 2008)

Pyroptosis A form of programmed cell death triggered by infection or cellular stress that is, unlike apoptosis, characterized by inflammation as it involves the activation of inflammasomes and caspase-1, leading to cell swelling, membrane rupture and the release of pro-inflammatory cytokines such as interleukin-1 (IL-1) and IL-18

Diabetes and long-term outcomes of ischaemic stroke: findings from Get With The Guidelines-Stroke