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the improvement effects of the NPs and MNs treatment groups were not obvious, while the GLP-1RAs@NPs, GLP-1RAs@NPs-WYRGRL and MNs/GLP-1RAs@NPs-WYRGRL groups could effectively alleviate cartilage destruction and osteophyte formation, especially the MNs/GLP-1RAs@NPs-WYRGRL group (Fig

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Depending on users response and glycemic control needs, the dose can be raised to 1 mg weekly after at least four weeks on 0.5 mg, and in some cases further to 2 mg weekly after at least four weeks on 1 mg

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