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Reactive oxygen species (ROS) and dysregulated iron homeostasis promote oxidative stress and immune dysregulation through activation of the NF-B pathway, impairing macrophage phagocytic activity and contributing to resistance to ferroptosis ( While several immune and inflammatory markers show promise, their clinical reliability remains insufficient

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of cd25(+)Cd4(+) regulatory cells that control intestinal inflammation

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Immediate risks include: Rectal perforation : Forceful insertion or improper technique can tear the rectal or colonic wall, potentially causing peritonitis, sepsis, and requiring emergency surgery