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Metformin acts on two different molecular pathways to enhance adult neural precursor proliferation/self-renewal and differentiation

Telomere length in cumulus cells is positively correlated with oocyte and embryo quality (Cheng et al., 2013)

Only with the recent development of locus-targeted tools, such as clustered regularly interspaced short palindromic repeats (CRISPR-Cas9) or transcription activator-like effector nucleases-based epigenetic editors, has it become feasible to directly test how defined chromatin or methylation changes influence neural and behavioral outcomes 9,183,184