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Western blot BF muscle from both the acute (intraoperative) and chronic (1 week) oIGF-1 infusion groups was homogenized in lysis buffer (Cell Signaling, Danvers, MA) with protease and phosphatase inhibitors (Sigma-Aldrich, St

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Christopher McGowan, MD, a gastroenterologist and obesity medicine specialist, told Medical News Today that: Losing weight at the expense of lean muscle can lead to future problems, including reduced basal metabolic rate, decreased strength, fitness, and tone, reduced bone density, and an increased risk of weight recurrence