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Glutathione S-conjugates are usually sequestered by distinct ABC transporters from the cytosol into the vacuole for degradation, although breakdown of glutathione, oxidized glutathione and glutathione S-conjugates also happens outside the vacuole 56

Severe vein irritation or phlebitis from IV administration

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The intervention is now being tested in larger NIH-funded trials with remote delivery via wireless headsets for at-home use