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Tightening the ROPE threshold to 0.5 kg did not materially change the overall interpretation (Figure 2E and Supplementary Table 5)

Common early effects include: Lower fasting blood glucose readings Reduced post-meal glucose spikes Decreased appetite, particularly for sweet or carbohydrate-rich foods Smaller portion sizes feel satisfying A noticeable quieting of intrusive thoughts about food Visible weight loss, when it occurs, takes longer than the glycemic effects

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