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Combination Therapy Use of OZEMPIC in Adults with Type 2 Diabetes Mellitus Combination with metformin and/or thiazolidinediones In a 56-week, double-blind trial (NCT01930188), 1231 patients with type 2 diabetes mellitus were randomized to OZEMPIC 0.5 mg once weekly, OZEMPIC 1 mg once weekly, or sitagliptin 100 mg once daily, all in combination with metformin (94%) and/or thiazolidinediones (6%)

It decreases basal corticotropin levels and blocks cortisol release, which explains its stress-reducing properties

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doi: 10.3390/ph18030376 159 LiJWMaoYMChenSLYeRFeiYRLiYet al