There was no significant difference in rates of heart attacks or overall bleeding between the different DOACs, which included rivaroxaban, apixaban, and dabigatran
However, in the early phases when GI side effects, fatigue, and caloric restriction are most significant, some women report temporary reductions in libido
Landmark trials, including the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) and Irbesartan Diabetic Nephropathy Trial (IDNT) studies, demonstrated that ARBs reduce progression to end-stage kidney disease (ESKD) in type 2 diabetes mellitus (T2DM) patients with proteinuria (112)
) He remains cautiously optimistic, however, because the bottom line is that you do see a reduction in cancer incidence with the GLP-1 agonists, he says, and its possible that reduction would be even greater if the researchers had only focused on patients with obesity or overweight