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doi:10.3945/jn.110.122697 Institute of Medicine

Gut Flora Changes : The introduction of semaglutide may alter the gut microbiome, which can contribute to gastrointestinal disturbances

A key cellular component to achieve this is the one-carbon metabolism comprising of the folate cycle and its tethered de novo nucleotide biosynthesis pathways and methionine cycle [48,50,51]