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The body is constantly recycling glutathione from the oxidized to the reduced version (for more on how this happens, this video is really helpful)

Most people notice reduced hunger within the first week, often between day 3 and day 7

Proctitis after external-beam radiotherapy for prostate cancer classified by Vienna Rectoscopy Score and correlated with EORTC/RTOG score for late rectal toxicity: results of a prospective multicenter study of 166 patients

The goal is finding the minimum effective dose that produces steady weight loss without intolerable side effects, not blindly following the escalation schedule to maximum dosing