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Name: when tirzepatide doesn't work Why Works Semaglutide Not losing weight on tirzepatide?
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Initial Combination Therapy with Metformin A total of 1091 patients with type 2 diabetes and inadequate glycemic control on diet and exercise participated in a 24-week, randomized, double-blind, placebo-controlled factorial study designed to assess the efficacy of sitagliptin as initial therapy in combination with metformin

Phase 2 data does not capture long-term safety

They fed the data into a machine learning algorithm called DRIAD (Drug Repurposing In AD), to predict which drugs are most likely to influence Alzheimers biology