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The open cardiovascular medicine journal

Microbiome-Derived Tryptophan Metabolites and Their Aryl Hydrocarbon Receptor-Dependent Agonist and Antagonist Activities

The combination therapy of SAHA (40 mg/kg, intraperitoneal injection every 3 days) and B7x neutralizing antibody (200 g/mouse, intraperitoneal injection every 2 days) significantly delayed tumor growth, with a tumor inhibition rate of 80.6%, and significantly increased the infiltration of CD8 + and CD4 + T cells in the tumor microenvironment (67)

The tissue-specific distribution of beta-3 receptors (concentrated in fat tissue) further enhances selectivity