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In addition, the profile of adverse effects is also changed in these two different therapeutic paradigms

Side Effects and Safety Profile Common Side Effects Gastrointestinal effects are the most frequently reported adverse events in clinical trials: Nausea (reported by 1233% of participants depending on dose) Diarrhea (1223%) Constipation (611%) Vomiting (59%) Decreased appetite (considered both a therapeutic effect and side effect) Abdominal pain (58%) Dyspepsia/heartburn (58%) These effects are most common during dose escalation and typically improve within 24 weeks at each new dose level

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