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However, drug efflux can be reduced through the use of BCRP inhibitors, such as gefitinib, a TKI that blocks BCRP transporter function, restoring drug sensitivity (263)

Qi X, Ng KT, Shao Y, Li CX, Geng W, Ling CC, Ma YY, Liu XB, Liu H, Liu J, et al

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Elderly, Cachectic, or Debilitated Patients: Life-threatening respiratory depression is more likely to occur in elderly, cachectic, or debilitated patients because they may have altered pharmacokinetics or altered clearance compared to younger, healthier patients (see WARNINGS, Life-Threatening Respiratory Depression)