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This comprehensive mechanism addresses appetite, energy expenditure, gastric function, and glucose homeostasis through distinct but complementary receptor systems, potentially explaining enhanced efficacy observed in combination approaches compared to monotherapies

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Gastric ulcer protection: BPC-157s original characterization was as an anti-ulcer peptide, and its gastroprotective effects against alcohol, capsaicin, stress-induced, and NSAID-induced gastric lesions have been demonstrated across numerous published studies