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Compared with healthy circulating neutrophils, those from patients with RA displayed a higher production of reactive oxygen species (ROS), as well as a higher expression of Fc receptors [8, 9]

What this mechanism does NOT prove: Demonstrating a receptor interaction or pathway upregulation in rat tissue or cell culture does not confirm a clinically meaningful effect in humans at any given dose

The focus was on genetic susceptibility, hormonal and behavioral risk factors, tumor microenvironment, novel biomarkers, novel imaging and liquid biopsy techniques, and novel treatment strategies, besides recent advances in bioinformatics and AI-based analyses